Rare Regency period fede locket ring c.1820.
Finely chased hands hold a turquoise and diamond set forget-me-not with a hinged locket compartment, opening to reveal the memento of a tiny glazed panel with the hair of the beloved.
Hand motifs were a popular romantic symbol in Georgian jewellery, the clasped hands called "fede" from ‘mani in fede’(hands joined in faith) representing  friendship, love, and betrothal. 
15 ct gold, Persian turquoise,old cut diamond.
I have had quite a few examples with hands holding a central flower but  this is unusual with the opening locket centre.
Size 6.